Castlevania: Season 1
Over the span of his 27 years (assuming we go by the birth date of the original, historical figure), Vlad Dracula went from son of a warlord to political prisoner to avenging general. He reclaimed his homeland of Wallachia from the Turks, then went on a bloody rampage killing all those that sided against him, demanding absolutely loyalty. Oh, and somewhere in that process he turned to the dark arts, became a vampire, and erected a giant mystical castle powered by alchemy and clockwork. You know, as you do.
By 1455 AD Dracula had built up such a reputation among the villagers in the surrounding areas that very few were stupid enough to venture close to the castle; Dracula was someone to be feared (as the rows of corpses mounted on stakes outside his castle indicated). Those that did venture into the seemingly deserted castle found only death and, normally, were never heard from again. One villager, though, found a different fate. She was Lisa of Lupu, a local healer, and she wasn't at the castle simply to thrill seek or to confront the dread demon that lived within the halls.
Spying someone in his castle, Dracula came from the shadows to confront the interloper. Lisa, however, did not cower back, instead standing up to the vampire. She explained that she was there to see his libraries, to explore the knowledge she had heard the castle contained, all its information on science and healing so she could become the best doctor the region had seen. Facing someone of noble intent, one who was willing to call him out on his own darkness but not shy away from it, Dracula found himself intrigued. He opened his castle to Lisa, allowing her to explore its labs and libraries, and the two of them struck up a fond and friendly connection.
- Season 1: "Witchbottle"
The relationship between Dracula and Lisa had only been inferred in the past, best explained in a few cut-scenes in Castlevania: Symphony of the Night. There we knew that Dracula had taken a wife, Lisa, and that she died later when a village burned her at the stake for being a witch. Beyond that, though, the details of how the two met and what their relationship was like was left only to speculation.
Although the series doesn't go into detail beyond this scene, this is the most we've ever seen for the relationship between Lisa and Dracula. This one sequence helps to shade in a lot about these characters and creates a much more elaborate, and interesting, dynamic for Dracula going forward in his story.